Carbohydrate recognition by Clostridium difficile toxin A.
Nat Struct Mol Biol
; 13(5): 460-1, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16622409
ABSTRACT
Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Bacterianas
/
Carboidratos
/
Clostridioides difficile
/
Enterotoxinas
/
Metabolismo dos Carboidratos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article