Evidence of astrogliosis in rat hippocampus after d-amphetamine exposure.
Prog Neuropsychopharmacol Biol Psychiatry
; 30(7): 1231-4, 2006 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-16631293
ABSTRACT
INTRODUCTION:
Psychostimulants such as amphetamine (AMPH) induce manic-like symptoms in humans and studies have suggested that bipolar disorder (BD) may be associated to dopamine dysfunction. Glial fibrillary acidic protein (GFAP) up-regulation is considered a marker of astrogliosis, and it has been associated to behavioral sensitization.PURPOSE:
We aimed to investigate the behavioral effects of acute and chronic AMPH on rat locomotion and assess GFAP levels in rat cortex and hippocampus.METHODS:
Rats were administered either acute (single dose) or chronic (seven days) d-amphetamine IP injection. Locomotion was assessed with an open-field test and GFAP immunoquantity was measured using ELISA.RESULTS:
Chronic, but not acute, administration of AMPH increased GFAP levels in rat hippocampus. No differences were observed in rat cortex.CONCLUSIONS:
Repeated exposure to AMPH leads to an astroglial response in the hippocampus of rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Astrócitos
/
Dextroanfetamina
/
Hipocampo
/
Estimulantes do Sistema Nervoso Central
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article