HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis-- involvement of ERK pathway.
FEBS Lett
; 580(11): 2779-87, 2006 May 15.
Article
em En
| MEDLINE
| ID: mdl-16650413
ABSTRACT
Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H(2)O(2)-induced cell death - a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H(2)O(2) (0-2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Sistema de Sinalização das MAP Quinases
/
Citomegalovirus
/
Células Endoteliais
/
Peróxido de Hidrogênio
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article