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Metronidazole in the treatment of rosacea: do formulation, dosing, and concentration matter?
Yoo, Jane; Reid, David C; Kimball, Alexa B.
Afiliação
  • Yoo J; Clinical Unit for Research Trials in Skin, Harvard Medical School, Boston, MA 02114, USA.
J Drugs Dermatol ; 5(4): 317-9, 2006 Apr.
Article em En | MEDLINE | ID: mdl-16673797
BACKGROUND: Topical metronidazole is commonly used in the management of rosacea. No consensus on the optimal formulation, concentration, or dosing regimen exists. PURPOSE: To assess the relative efficacy of metronidazole cream, gel, and lotion at concentrations of 0.75% and 1%, in dosing regimens of once and twice daily. METHODS: A meta-analysis of published metronidazole efficacy rates was performed. RESULTS: In non-weighted analysis, the mean efficacy was 28.2% (95% confidence interval [CI], 22.0%-34.4%) for the cream, 38.4% (95% CI, 18.4%-58.4%) for the gel, and 35% for the lotion. Confidence intervals for QD versus BID dosing and 0.75% versus 1% concentrations also overlapped. In weighted analysis, the mean reduction was 31.3% for the cream, 22.1% for the gel, and 35% for the lotion. CONCLUSIONS: Metronidazole cream, gel, and lotion vehicles have similar efficacies. There were no substantial differences between concentrations of 0.75% and 1%, or between once daily and twice daily regimens.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rosácea / Metronidazol Tipo de estudo: Clinical_trials / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rosácea / Metronidazol Tipo de estudo: Clinical_trials / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article