The role of Paraxial Protocadherin in Xenopus otic placode development.
Biochem Biophys Res Commun
; 345(1): 239-47, 2006 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-16678122
ABSTRACT
Vertebrate inner ear develops from its rudiment, otic placode, which later forms otic vesicle and gives rise to tissues comprising the entire inner ear. Although several signaling molecules have been identified as candidates responsible for inner ear specification and patterning, many details remain elusive. Here, we report that Paraxial Protocadherin (PAPC) is required for otic vesicle formation in Xenopus embryos. PAPC is expressed strictly in presumptive otic placode and later in otic vesicle during inner ear morphogenesis. Knockdown of PAPC by dominant-negative PAPC results in the failure of otic vesicle formation and the loss of early inner ear markers Sox9 and Tbx2, suggesting the requirement of PAPC in the early stage of otic vesicle development. However, PAPC alone is not sufficient to induce otic placode formation.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Xenopus laevis
/
Caderinas
/
Padronização Corporal
/
Proteínas de Xenopus
/
Orelha Interna
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article