The detection of sedatives in hair and nail samples using tandem LC-MS-MS.
Forensic Sci Int
; 166(1): 58-67, 2007 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-16707239
ABSTRACT
Drug screening methods were developed to detect alprazolam, clobazam, clonazepam, diazepam, midazolam, oxazepam, temazepam, triazolam, zopiclone, and selected metabolites in human hair and nail samples employing liquid-liquid extraction and tandem liquid chromatography-mass spectrometry (LC-MS-MS). Hair and nail samples were obtained from patients who had recently discontinued or were currently prescribed one or more of the targeted drugs. Prazepam was used as the internal standard for all compounds. Some components in the hair matrix gave the same transitions as some of the analytes but did not compromise the analyses because their retention times differed from those for the target compounds. The analytical run time was 8-10min. Results of the hair analysis of a DFSA victim are also presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estupro
/
Cabelo
/
Hipnóticos e Sedativos
/
Unhas
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article