Hypermethylation of CpG island in the promoter region of CALCA in acute lymphoblastic leukemia with central nervous system (CNS) infiltration correlates with poorer prognosis.
Leuk Res
; 30(7): 891-4, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16712930
ABSTRACT
Promoter hypermethylation occurs early in leukemogenesis and seems to be associated with poor prognosis in acute lymphoblastic leukemia (ALL). The methylation status of the promoter region of six genes was analyzed in 71 children with ALL using methylation specific PCR (MSP). Calcitonin (CALCA) and E-cadherin (CDH1) were the most frequently methylated genes in this group of patients. Considering the patients with central nervous system (CNS) infiltration, the estimated 2-year overall survival (OS) was 20% for those with methylation in CALCA promoter and 85% for those without (p=0.001). Our results suggest that the hypermethylation of CALCA promoter is a promising prognostic marker and may predict a higher risk for ALL patients with CNS infiltration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calcitonina
/
Regiões Promotoras Genéticas
/
Neoplasias do Sistema Nervoso Central
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Ilhas de CpG
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Metilação de DNA
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Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article