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Recognition and management of heparin-induced thrombocytopenia in pediatric cardiopulmonary bypass patients.
Boshkov, Lynn K; Kirby, Aileen; Shen, Irving; Ungerleider, Ross M.
Afiliação
  • Boshkov LK; Department of Pathology and Medicine, Doernbecher Children's Hospital, Oregon Health and Science University, Portland, Oregon 97231, USA. boshkovl@ohsu.edu
Ann Thorac Surg ; 81(6): S2355-9, 2006 Jun.
Article em En | MEDLINE | ID: mdl-16731103
Repeated exposure to unfractionated heparin is the rule in many congenital heart disease patients. Heparin-induced thrombocytopenia occurs in 1% to 3% of adult cardiac surgeries, and carries high thrombotic morbidity (38% to 81%) and mortality (approximately 28%). Although heparin-induced thrombocytopenia appears to be infrequent in pediatric patients, particularly neonates, our evolving experience suggests postcardiopulmonary bypass congenital heart disease patients may be at increased risk. Diagnostic and therapeutic challenges include frequency of thrombocytopenia after cardiopulmonary bypass, imperfect laboratory testing, lack of established dosing of alternative anticoagulants (such as argatroban and lepirudin), and increased anticoagulant-related bleeding in young children.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Trombocitopenia / Heparina / Ponte Cardiopulmonar / Anticoagulantes Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Ano de publicação: 2006 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Trombocitopenia / Heparina / Ponte Cardiopulmonar / Anticoagulantes Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Ano de publicação: 2006 Tipo de documento: Article