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Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria.
Raffa, Robert B; Baron, David A; Tallarida, Ronald J.
Afiliação
  • Raffa RB; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140, USA. robert.raffa@temple.edu
Eur J Pharmacol ; 540(1-3): 200-1, 2006 Jul 01.
Article em En | MEDLINE | ID: mdl-16737694
ABSTRACT
Previous investigators have provided radioimmunological and immunocytochemical evidence for an enkephalinergic (opioid) system in Planaria and described naloxone-sensitive qualitative behavioral responses to kappa-opioid receptor agonists. We report the application of Schild-analysis to the antagonism of a selective kappa agonist (U-50,488H) by a selective kappa antagonist (nor-BNI) in a quantitative in vivo endpoint. The results provide further evidence of a kappa-opioid-like receptor in planarians.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Planárias / Receptores Opioides kappa / (trans)-Isômero de 3,4-dicloro-N-metil-N-(2-(1-pirrolidinil)-ciclo-hexil)-benzenoacetamida / Naltrexona Tipo de estudo: Diagnostic_studies / Qualitative_research Limite: Animals Idioma: En Ano de publicação: 2006 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Planárias / Receptores Opioides kappa / (trans)-Isômero de 3,4-dicloro-N-metil-N-(2-(1-pirrolidinil)-ciclo-hexil)-benzenoacetamida / Naltrexona Tipo de estudo: Diagnostic_studies / Qualitative_research Limite: Animals Idioma: En Ano de publicação: 2006 Tipo de documento: Article