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Controlling stem cell proliferation: CKIs at work.
Bruggeman, Sophia W M; van Lohuizen, Maarten.
Afiliação
  • Bruggeman SW; Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Cell Cycle ; 5(12): 1281-5, 2006 Jun.
Article em En | MEDLINE | ID: mdl-16760652
ABSTRACT
The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Proteínas Inibidoras de Quinase Dependente de Ciclina Limite: Animals / Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Proteínas Inibidoras de Quinase Dependente de Ciclina Limite: Animals / Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article