Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes.

Mizuta, Satoshi; Shibata, Norio; Ogawa, Shinichi; Fujimoto, Hiroyuki; Nakamura, Shuichi; Toru, Takeshi

Mizuta, Satoshi; Shibata, Norio; Ogawa, Shinichi; Fujimoto, Hiroyuki; Nakamura, Shuichi; Toru, Takeshi.

Afiliação

Mizuta S; Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.

Chem Commun (Camb) ; (24): 2575-7, 2006 Jun 28.

Article em En | MEDLINE | ID: mdl-16779482

RESUMO

The first Lewis acid-catalyzed trifluoromethylation reactions of aldehydes with Me3SiCF3 under TiF4/DMF, Ti(O iPr)4/DMF and Cu(OAc)2/dppp/toluene conditions are described. We have successfully applied this methodology to the difluoromethylation of aldehydes using Me3SiCF2SePh, Me3SiCF2P(O)OEt2 and Me3SiCF2SPh.

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Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2006 Tipo de documento: Article

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PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2006 Tipo de documento: Article