Arginylation of beta-actin regulates actin cytoskeleton and cell motility.
Science
; 313(5784): 192-6, 2006 Jul 14.
Article
em En
| MEDLINE
| ID: mdl-16794040
ABSTRACT
Posttranslational arginylation is critical for mouse embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are unknown. We found that beta-actin was arginylated in vivo to regulate actin filament properties, beta-actin localization, and lamella formation in motile cells. Arginylation of beta-actin apparently represents a critical step in the actin N-terminal processing needed for actin functioning in vivo. Thus, posttranslational arginylation of a single protein target can regulate its intracellular function, inducing global changes on the cellular level, and may contribute to cardiovascular development and angiogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Citoesqueleto de Actina
/
Movimento Celular
/
Actinas
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article