Effects of electroconvulsive seizures on Na(+),K(+)-ATPase activity in the rat hippocampus.
Neurosci Lett
; 404(3): 254-7, 2006 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-16797841
ABSTRACT
Although several advances have occurred concerning the use of electroconvulsive therapy, little progress has been made in understanding the mechanisms underlying its therapeutic or side effects. Na(+),K(+)-ATPase is an important enzyme of central nervous system, responsible for ionic gradient maintenance and consumption of approximately 40-50% of brain ATP. This work was performed in order to determine Na(+),K(+)-ATPase activity after acute and chronic electroconvulsive shock. Results showed an inhibition of Na(+),K(+)-ATPase activity in the hippocampus 48 h, 7, 30, 60 and 90 days after a single electroconvulsive shock. Chronic treatment diminished the enzyme activity in the hippocampus 7 and 30 days after electroconvulsive (ECS) sessions. Our findings demonstrated that Na(+),K(+)-ATPase activity is altered by ECS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
ATPase Trocadora de Sódio-Potássio
/
Eletroconvulsoterapia
/
Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article