Genomic instability of human aberrant crypt foci measured by inter-(simple sequence repeat) PCR and array-CGH.
Mutat Res
; 601(1-2): 30-8, 2006 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-16806294
ABSTRACT
Aberrant crypt foci (ACF) are the earliest identifiable neoplastic lesions in the colon. Thirty-two ACFs were examined for genomic instability in forms detectable either by inter-(simple sequence repeat) PCR or by array comparative genomic hybridization [array-CGH]. One-fourth of ACFs revealed moderate instability by inter-(simple sequence repeat) PCR; none showed amplifications or deletions on array-CGH. The absence of genomic events detectible by BAC array-CGH indicates early events in colorectal tumor progression are typically smaller than the approximate 150 kb size of a BAC clone insert.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
/
Neoplasias Colorretais
/
Reação em Cadeia da Polimerase
/
Instabilidade Genômica
/
Hibridização de Ácido Nucleico
Limite:
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article