Repeated injections of piracetam improve spatial learning and increase the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in aged rats.
Funct Neurol
; 6(2): 107-11, 1991.
Article
em En
| MEDLINE
| ID: mdl-1680776
ABSTRACT
Repeated injections of piracetam (400 mg/kg, i.p. once a day for 15 days) to 16-month old rats led to an improved performance on an 8-arm radial maze, used as a test for spatial learning. This effect was accompanied by a greater ability of excitatory amino acids (ibotenate and glutamate) to stimulate [3H]inositol-monophosphate formation in hippocampal slices incubated in the presence of 10 mM Li+. Repeated administration of piracetam did not induce changes in excitatory amino acid-stimulated polyphosphoinositide hydrolysis in hippocampal slices prepared from 2-month old animals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orientação
/
Fosfatidilinositóis
/
Piracetam
/
Rememoração Mental
/
Córtex Cerebral
/
Receptores de Neurotransmissores
/
Aprendizagem por Discriminação
/
Glutamatos
/
Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article