AMP-activated protein kinase signaling in metabolic regulation.
J Clin Invest
; 116(7): 1776-83, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16823475
ABSTRACT
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and lipid oxidation to produce energy, while turning off energy-consuming processes including glucose and lipid production to restore energy balance. AMPK controls whole-body glucose homeostasis by regulating metabolism in multiple peripheral tissues, such as skeletal muscle, liver, adipose tissues, and pancreatic beta cells--key tissues in the pathogenesis of type 2 diabetes. By responding to diverse hormonal signals including leptin and adiponectin, AMPK serves as an intertissue signal integrator among peripheral tissues, as well as the hypothalamus, in the control of whole-body energy balance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Proteínas Serina-Treonina Quinases
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Metabolismo Energético
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Complexos Multienzimáticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article