Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines.
Bioorg Med Chem Lett
; 16(18): 4777-9, 2006 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-16844373
ABSTRACT
In this paper, we report the synthesis of diastereomerically pure N-(4-substituted-2,4-diaminobutanoyl)piperidines. These compounds were prepared to investigate the influence of the 4-substitution on the dipeptidyl peptidase II (DPP II) activity and selectivity of the parent N-(2,4-diaminobutanoyl)piperidine. The (4S)-methyl compound showed subnanomolar inhibition, comparable with the parent compound. The (4R)-methyl group or bigger substituents decreased the activity.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Inibidores de Proteases
/
Dipeptidil Peptidases e Tripeptidil Peptidases
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article