Stimulation of CD2-negative T cells by staphylococcal enterotoxin superantigens.
Immunol Lett
; 29(3): 219-22, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1685147
ABSTRACT
A minor fraction of CD3+ T cells lacks expression of the CD2 antigen, which is the target for an "alternative" T cell activation pathway. CD2-CD3+ T cells can be stimulated by anti-CD3 or anti-T cell receptor (TCR) antibodies, indicating that the CD3/TCR signal transduction pathway functions in the absence of cell surface CD2. In the present study we have analyzed whether CD2-CD3+ T cells also respond to antigen stimulation. We show here that cloned CD2-negative T cells expressing the alpha/beta TCR are activated by one or several staphylococcal enterotoxin "superantigens". Activation of CD2-CD3+ T cell clones by staphylococcal enterotoxins resulted in IL-2 production and/or proliferative activity, and was dependent on the presence of HLA class II-bearing feeder cells. These data demonstrate that T cells can recognize (and respond to) antigen in the absence of a functional CD2 molecule.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus
/
Ativação Linfocitária
/
Receptores Imunológicos
/
Linfócitos T
/
Antígenos de Diferenciação de Linfócitos T
/
Enterotoxinas
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article