N-hexacosanol reverses diabetic induced muscarinic hypercontractility of ileum in the rat.
Eur J Pharmacol
; 545(2-3): 177-84, 2006 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-16872599
ABSTRACT
Diabetic neuropathy, a major complication of diabetes mellitus, is associated with development of gastrointestinal motility dysfunction and autonomic neuropathy. N-hexacosanol has neurotrophic effects and exhibits a wide variety of biological actions. In this study, we investigated the effects of cyclohexenonic long-chain fatty alcohol (N-hexacosanol) on streptozotocin-diabetic hypercontractility in the rat ileum longitudinal muscles. Treatment with N-hexacosanol did not alter the diabetic status of the animals, i.e., body weight, serum glucose, and serum insulin levels, but significantly restored the thickness of intestine wall and ameliorated diabetes-induced hypercontractility of the rat ileum in a dose-dependent manner. Furthermore, N-hexacosanol reversed the diabetes-induced upregulation of intestinal muscarinic M(2) and M(3) receptors mRNAs in the streptozotocin-diabetic rats. These results indicate that N-hexacosanol has therapeutic effects on hypercontractility in the diabetic ileum by ameliorating overexpression of muscarinic M(2) and M(3) receptors mRNAs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptor Muscarínico M2
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Receptor Muscarínico M3
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Diabetes Mellitus Experimental
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Neuropatias Diabéticas
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Álcoois Graxos
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Íleo
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Contração Muscular
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article