Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders.
J Med Chem
; 49(17): 5047-50, 2006 Aug 24.
Article
em En
| MEDLINE
| ID: mdl-16913694
ABSTRACT
The synthesis and evaluation of inhibitors of activated protein C (aPC) are reported. This serine protease is partly responsible for the degradation of factor VIIIa, involved in the regulation of bleeding in hemophilia A. Benzamidine-containing derivatives were found to be potent aPC inhibitors, some of them showing selectivity against the procoagulant protease thrombin. Moreover, compound 1 significantly restored the generation of thrombin in hemophiliac plasma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzamidinas
/
Proteína C
/
Inibidores de Serina Proteinase
/
Hemofilia A
/
Hemorragia
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article