Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives.
Bioorg Med Chem
; 14(22): 7501-11, 2006 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-16919461
ABSTRACT
A series of phenylpiperazine derivatives were synthesized and evaluated for their neuropeptide Y (NPY) Y5 receptor antagonistic activities. The benzindane portion of 2 was replaced by 1-phenylpiperazine, resulting in novel urea derivative 3f. Subsequent optimization of the phenylpiperazine template by substitution of the phenyl moiety resulted in a series of (2-methanesulfonamidephenyl)piperazine derivatives that showed potent binding affinity and antagonistic activity for the Y5 receptor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Receptores de Neuropeptídeo Y
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article