MMM: a sequence-to-structure alignment protocol.
Bioinformatics
; 22(21): 2691-2, 2006 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-16928737
ABSTRACT
MOTIVATION Accurate alignment of a target sequence to a template structure continues to be a bottleneck in producing good quality comparative protein structure models. RESULTS:
Multiple Mapping Method (MMM) is a comparative protein structure modeling server with an emphasis on a novel alignment optimization protocol. MMM takes inputs from five profile-to-profile based alignment methods. The alternatively aligned regions from the input alignment set are combined according to their fit in the structural environment of the template structure. The resulting, optimally spliced MMM alignment is used as input to an automated comparative modeling module to produce a full atom model.AVAILABILITY:
The MMM server is freely accessible at http//www.fiserlab.org/servers/mmm
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Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Software
/
Modelos Moleculares
/
Análise de Sequência de Proteína
Tipo de estudo:
Evaluation_studies
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article