Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.
Diabetes
; 55(9): 2401-11, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16936187
ABSTRACT
Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians. Destruction of damaged retina by photocoagulation remains the primary treatment nearly 50 years after its introduction. The diabetes pandemic requires new approaches to understand the pathophysiology and improve the detection, prevention, and treatment of retinopathy. This perspective considers how the unique anatomy and physiology of the retina may predispose it to the metabolic stresses of diabetes. The roles of neural retinal alterations and impaired retinal insulin action in the pathogenesis of early retinopathy and the mechanisms of vision loss are emphasized. Potential means to overcome limitations of current animal models and diagnostic testing are also presented with the goal of accelerating therapies to manage retinopathy in the face of ongoing diabetes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retinopatia Diabética
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article