Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography.
J Neurosci Res
; 84(6): 1350-7, 2006 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-16941649
ABSTRACT
Parkin is the causal gene of autosomal recessive juvenile parkinsonism (AR-JP). Dopamine (DA) metabolism has been linked to Parkinson's disease (PD). To understand the pathogenesis of AR-JP, we generated parkin-deficient mice to assess the status of DA signaling pathway and examine DA release and DA receptor by ex vivo autoradiography. Ex vivo autoradiography using [11C]raclopride showed a clear decrease in endogenous DA release after methamphetamine challenge in parkin-deficient mice. Furthermore, parkin deficiency was associated with considerable upregulation of DA (D1 and D2) receptor binding in vivo in the striatum and increased DA levels in the midbrain. Our results suggest that dopaminergic neurons could behave abnormally before neuronal death.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dopamina
/
Neostriado
/
Ubiquitina-Proteína Ligases
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article