Chemokine gene polymorphisms in idiopathic anterior uveitis.
Cytokine
; 35(1-2): 29-35, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16950632
ABSTRACT
OBJECTIVES:
The aim of this study was to determine whether there are any associations between single nucleotide polymorphisms of the chemokine genes IL-8, MCP-1, their corresponding receptors CXCR1 and CCR2 and disease outcome in patients with acute idiopathic anterior uveitis.METHODS:
60 Caucasian patients with idiopathic acute recurrent anterior uveitis together with 120 healthy Caucasian control subjects were tested for the presence of 16 bi-allelic polymorphisms and HLA-B27 using polymerase chain reaction in association with sequence-specific primers with mismatches at the 3' end. The genetic data was then compared between patients and controls, and within the patient group itself for association with clinical disease outcome.RESULTS:
As expected, the frequency of HLA-B27 was significantly higher in the patient group than the control group (63.33% versus 15.83%; Pearson's P<0.0001, Fisher's P<0.0001). In addition, the frequency of the T allele of MCP-1 63555 was found to be significantly higher in the control group when compared to the patient group (P=0.0160).CONCLUSION:
This study describes an association between acute anterior uveitis and MCP-1 63555 polymorphisms where the T allele may be a protective marker against the disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uveíte Anterior
/
Quimiocinas
/
Polimorfismo de Nucleotídeo Único
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article