Reserpine-induced model of stress suppresses mucosal immunity.
Immunol Cell Biol
; 84(6): 537-42, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-16956388
ABSTRACT
Stress contributes significantly to the development of many diseases. In clinical studies, a strong correlation between depression and immune dysfunction has been shown. Our previous studies indicated that sympathetic innervation can regulate intestinal mucosal immunity through sympathetic synapses, but the mechanism in stress/depression-induced intestinal immune deficiency was unclear. Using a mouse model in which behavioural stress/depression is chemically induced by reserpine, it is found that there is a substantial deficiency of intestinal local humoral and particularly specific antibody response to the antigen stimulation in reserpine-treated group. No significant difference of CD4+, CD8+ or Mac1+ cells between reserpine-treated and control groups was detected in the intestine. This deficiency is closely correlated with stress/depression. A possible correlation between stress, cytokine secretion and humoral immunity in vivo is postulated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reserpina
/
Estresse Psicológico
/
Imunidade nas Mucosas
/
Mucosa Intestinal
/
Formação de Anticorpos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article