The solution structure of the invasive tip complex from Afa/Dr fibrils.
Mol Microbiol
; 62(2): 356-66, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16965519
ABSTRACT
Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adesinas de Escherichia coli
/
Proteínas de Escherichia coli
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article