RNAi in Haemonchus contortus: a potential method for target validation.
Trends Parasitol
; 22(11): 495-9, 2006 Nov.
Article
em En
| MEDLINE
| ID: mdl-16971180
ABSTRACT
RNA interference (RNAi) is a method for the functional analysis of specific genes, and is particularly well developed in the free-living nematode Caenorhabditis elegans. There have been several attempts to apply this method to parasitic nematodes. In a recent study undertaken in Haemonchus contortus, Geldhof and colleagues concluded that, although a mechanism for RNAi existed, the methods developed for RNAi in C. elegans had variable efficacy in this parasitic nematode. The potential benefits of RNAi are clear; however, further studies are required to characterize the mechanism present in parasitic nematodes, and to improve culture systems for these nematodes to monitor the long-term effects of RNAi. Only then could RNAi become a reliable assay of gene function.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Marcação de Genes
/
Interferência de RNA
/
Haemonchus
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article