[Molecular anomalies of the Y chromosome: Consequences on male fertility]. / Polymorphismes du chromosome Y et fertilité masculine.
Gynecol Obstet Fertil
; 34(10): 885-93, 2006 Oct.
Article
em Fr
| MEDLINE
| ID: mdl-16979369
ABSTRACT
Molecular anomalies of the Y chromosome leading to male infertility are mainly microdeletions of the long arm of the Y chromosome. Three recurrently deleted portions of the long arm are the AZFa, AZFb and AZFc (AZF Azoospermia Factor) regions. Complete deletions of the AZFc region are found in 10% of cases of severe male infertility. In addition to the AZF deletions, certain classes of Y chromosome (haplogroups) may also predispose to male infertility and could be transmitted to future male descents by various Assisted Reproductive Techniques (ART). Since the first discovery of microdeletions, the sequence of the Y chromosome has become available, revealing the mechanisms underlying deletion formation and also resulting in a coherent screening strategy. Recently, partial deletions of the AZF regions have been described. The significance of these deletions in the clinical context remains to be defined.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Cromossomos Humanos Y
/
Infertilidade Masculina
Limite:
Humans
/
Male
Idioma:
Fr
Ano de publicação:
2006
Tipo de documento:
Article