[Study on the genotyping and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau].
Zhonghua Liu Xing Bing Xue Za Zhi
; 27(5): 412-5, 2006 May.
Article
em Zh
| MEDLINE
| ID: mdl-16981338
ABSTRACT
OBJECTIVE:
To study the distribution of genomovars and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau.METHODS:
Primer pairs targeting the twenty-two different regions(DFRs) were designed for detecting the presence or deletion of each DFR in 297 strains isolated from the Qinghai-Tibet Plateau.RESULTS:
9 genomovars, i. e. Genomovar 1, 5, 6, 7, 8, 10, 11, new type and Ype-ancestor were identified in the Marmota himalayana plague focus of the Qinghai-Tibet Plateau. Among these genomovars, genomovar 5,8 and 10 were dominant types. The total rate of the three genomovars was 80.6% (204/253) and the genomovars in different regions were different. All of 44 strains of Y. pestis in the Microtus fuscus plague focus of the Qinghai-Tibet Plateau belonged to genomovar 14.CONCLUSION:
The distribution of genomovars of Y. pestis in the Qinghai-Tibet plateau had remarkable characteristics geographically. Based on the distribution of genomovars of Y. pestis, the routes of transmission and microevolution of Y. pestis were proposed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peste
/
Yersinia pestis
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article