Cysteine cathepsins: multifunctional enzymes in cancer.
Nat Rev Cancer
; 6(10): 764-75, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16990854
ABSTRACT
Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post-transcriptional modification. Their localization within intracellular lysosomes often changes during neoplastic progression, resulting in secretion of both inactive and active forms and association with binding partners on the tumour cell surface. Secreted, cell-surface and intracellular cysteine cathepsins function in proteolytic pathways that increase neoplastic progression. Direct proof for causal roles in tumour growth, migration, invasion, angiogenesis and metastasis has been shown by downregulating or ablating the expression of individual cysteine cathepsins in tumour cells and in transgenic mouse models of human cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cisteína Endopeptidases
/
Inibidores de Cisteína Proteinase
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article