Sequence variability of retroviral particles derived from human melanoma cells melanoma-associated retrovirus.
Virus Res
; 123(2): 211-5, 2007 Feb.
Article
em En
| MEDLINE
| ID: mdl-17005285
ABSTRACT
We have shown that melanoma cells produce viral particles that contain sequences which are homologous to human endogenous retroviruses. In this study particles derived from different melanoma cell lines and from melanoma cells of a lymph node metastasis were characterized. We determined the density and the reverse transcriptase (RT) activity of viral particles. Furthermore, we analyzed the sequence variability of multiple clones of each particle preparation. The particles were found to package sequences, which vary for each of the analyzed cell lines. Moreover, even particles derived from the same cell line contain heterologous sequences.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Genoma Viral
/
Retrovirus Endógenos
/
Melanoma
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article