Agonist binding to purified glycine receptor reconstituted into giant liposomes elicits two types of chloride currents.
FEBS Lett
; 276(1-2): 54-8, 1990 Dec 10.
Article
em En
| MEDLINE
| ID: mdl-1702396
ABSTRACT
Using 'inside-out' membrane patches obtained from reconstituted giant liposomes containing purified glycine receptor from rat spinal cord, we have detected chloride currents elicited in response to the presence of the agonists glycine or beta-alanine. Regardless of the agonist employed, two different patterns of single channel currents could be detected, which differ in their main conductance, complexity of substates and opening frequency. In agreement with the expectations of glycine receptor heterogeneity suggested recently at the mRNA and cDNA level, our results indicate the existence of functionally different glycine receptors in the adult rat spinal cord.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Neurotransmissores
/
Glicina
/
Canais Iônicos
/
Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article