Design of potent inhibitors of human beta-secretase. Part 2.
Bioorg Med Chem Lett
; 17(1): 78-81, 2007 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-17049233
We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Sulfonamidas
/
Carbamatos
/
Secretases da Proteína Precursora do Amiloide
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article