Polyethylene glycol enhances colonic barrier function and ameliorates experimental colitis in rats.
Int J Colorectal Dis
; 22(6): 571-80, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17061105
ABSTRACT
OBJECTIVE:
Polyethylene glycol (PEG) has been suggested to protect against pathogen colonization by improving colonic barrier function. We aimed to establish whether PEG 4000 affects colonic barrier function and the development of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in rats. MATERIALS ANDMETHODS:
PEG was included in the drinking water for a period of 48 h before intracolonic administration of TNBS. RESULTS ANDDISCUSSION:
PEG increased colonic surface hydrophobicity and diminished luminal bacterial load. Moreover, PEG markedly reduced mucosal damage and inflammation induced by TNBS. This protection effect appeared to be independent of its laxative properties since the laxatives mannitol or senna extracts had no effect on TNBS colitis. Using everted colonic sacs, pretreatment with PEG produced a lasting reduction in epithelial permeability to mannitol and dextran-70 K that correlated with decreased surface hydrophobicity.CONCLUSION:
Our results suggest that the protective effect of PEG on TNBS colitis is associated with reinforcement of the epithelial barrier.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Colite
/
Colo
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article