The vasohibin family: a negative regulatory system of angiogenesis genetically programmed in endothelial cells.
Arterioscler Thromb Vasc Biol
; 27(1): 37-41, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17095714
ABSTRACT
Biological phenomena are under the precise control by the genome. For the regulation of angiogenesis, proangiogenic genes such as VEGFs and angiopoietins are highly conserved, act specifically on endothelial cells, and play a fundamental role. In this sense, nature should prepare specific antiangiogenic genes as well. However, this counterpart of genomic regulation of angiogenesis remains to be established. We recently isolated a novel endothelium-derived angiogenesis inhibitor and named it vasohibin. Vasohibin is dominantly expressed in endothelial cells, induced by the stimulation with VEGF or FGF-2, and selectively affects on endothelial cells and inhibits angiogenesis. Although the mechanism of how vasohibin inhibits angiogenesis remains to be elucidated, our discovery of vasohibin as an endothelium-derived VEGF-inducible angiogenesis inhibitor should shed light on the genomic basis of the negative regulation of angiogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Proteínas de Ciclo Celular
/
Neovascularização Fisiológica
/
Retroalimentação Fisiológica
/
Neovascularização Patológica
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article