[Effect of biminne on vascular permeability of nasal mucosa in allergic rhinitis rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
; 26(10): 918-21, 2006 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-17121045
ABSTRACT
OBJECTIVE:
To investigate whether the effect of Biminne on allergic rhinitis (AR) was through improving vascular permeability of nasal mucosa.METHODS:
Rat's model in Biminne-treated group and model group was induced by intraperitoneal injection of ovalbumin (OVA) and aluminum hydroxide gel suspension Biminne-treated rats were orally given Biminne suspension from the 8th day to the 17th day. On the 18th day, Evan's blue dye (EBD) in the nasal perfusate was detected to assess the vascular permeability.RESULTS:
EBD concentration was higher in the model rats than that in the normal rats, and lower in the Biminne-treated rats than that in the model rats (both P < 0.01).CONCLUSION:
Biminne could improve vascular permeability of nasal mucosa in sensitized rats, which may be the mechanism of its clinical effect on AR.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Permeabilidade Capilar
/
Medicamentos de Ervas Chinesas
/
Rinite Alérgica Perene
/
Mucosa Nasal
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article