Viscum album aqueous extract induces NOS-2 and NOS-3 overexpression in Guinea pig hearts.
Nat Prod Res
; 20(13): 1176-82, 2006 Nov.
Article
em En
| MEDLINE
| ID: mdl-17127505
ABSTRACT
Viscum album L. aqueous extract, on the Langendorff isolated and perfused heart model, decreases coronary vascular resistance, when compared to control group (36.00 +/- 2.00 vs. 15.80 +/- 1.96 dyn s cm-5). Our data support the fact that this mechanism involves NOS-2 and NOS-3 overexpression (4.65 and 7.89 times over control, respectively), which is correlated with increases in NO (6.24 +/- 2.49 vs. 147.95 +/- 2.79 pmol) and cGMP production (43.94 +/- 2.00 vs. 74.81 +/- 1.96 pmol mg-1 of tissue), compared to control values. Such an effect is antagonized by gadolinium(III) chloride, L-NAME and ODQ. Therefore, coronary vasodilator effect elicited by V. album L. aqueous extract is mediated by the NO/sGC pathway.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Viscum album
/
Óxido Nítrico Sintase Tipo I
/
Óxido Nítrico Sintase Tipo III
/
Miocárdio
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article