A preliminary study on the interaction of fluvoxamine and adenosine receptor on isolated Guinea-pig atria.
Int J Neurosci
; 116(12): 1491-9, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17145683
ABSTRACT
Fluvoxamine (FLV), a selective serotonin reuptake inhibitor (SSRI) antidepressant, caused a dose-dependent decrease in rate and contractile force of the isolated guinea-pig atria. These effects significantly blocked by DPCPX, a specific A(1) receptor antagonist. Theophylline, an A(1)/A(2A) receptor antagonist, also prevented the inotropic and chronotropic effect of FLV. The atrium was dissected out and suspended in modified Krebs solution under physiologic conditions. Drug was added to the solution. The changes in rate and contractions were measured using a physiograph. The data indicate that DPCPX and theophylline prevent the inotropic and chronotropic effects of FLV on atria, but these effects were not prevented by atropine and DMPX, an A(2) receptor antagonist. Adenosine A(1) receptor blockade attenuates FLV effects in isolated guinea-pig atria.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fluvoxamina
/
Inibidores Seletivos de Recaptação de Serotonina
/
Receptores Adrenérgicos alfa 2
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Receptores Adrenérgicos alfa 1
/
Coração
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article