Synthesis of synthetic small molecule transcription factors (STF).
Nucleic Acids Symp Ser (Oxf)
; (50): 29-30, 2006.
Article
em En
| MEDLINE
| ID: mdl-17150801
ABSTRACT
External control of gene expression by small synthetic molecules represents a challenge in chemistry. Here we discuss the synthetic aspects of small molecule transcription factor mimics including a molecule we call STF1 (1). STF1 stimulates the transcription of a reporter gene controlled by specific DNA elements and behaves just as a naturally occurring transcription factor. However, STF1 had limited cell permeability, even though the hairpin-polyamide-FITC conjugate and the wrenchnolol (2) are cell permeable as separate compounds. Systematic synthetic exploration of STF1 analogs (STFs), by optimizing the physical properties of the molecule, is expected to increase its cell permeability for biological studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Fatores de Transcrição
/
Fluoresceínas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article