Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report.
Growth Horm IGF Res
; 17(1): 54-7, 2007 Feb.
Article
em En
| MEDLINE
| ID: mdl-17166755
ABSTRACT
OBJECTIVE:
Overexpression of IGF-I occurs in tumors diagnosed in childhood (osteosarcoma, Wilms tumor, neuroblastoma, etc.) and in adults (breast, ovaries, colon and prostate cancer). The aim of our study was to establish the prevalence of malignancies in states of congenital IGF-I deficiency.SUBJECTS:
We surveyed 222 patients with congenital IGF-I deficiency (Laron syndrome, GH gene deletion, GHRH receptor defects and IGF-I resistance) and 338 first and second-degree relatives.RESULTS:
None of the IGF-I deficient patients had cancer, whereas 9-24% of the family members had a history of malignancy.CONCLUSIONS:
Congenital IGF-I deficiency acts as a protecting factor for the development of cancer.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Doenças Genéticas Inatas
/
Neoplasias
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article