Novel synthesis of N(4)-substituted 1,4-benzodiazepine-2,5-diones using poly(ethylene glycol) as soluble polymer support.
Comb Chem High Throughput Screen
; 9(10): 743-6, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17168679
ABSTRACT
An efficient method for the liquid-phase combinatorial synthesis of N4-substituted 1,4-benzodiazepine-2,5-diones has been developed. Poly(ethylene glycol) (PEG) stepwise reacted with bromoacetyl bromide, a primary amine and 2-azidobenzoic acid to give a potential PEG-bound dipeptide, which was reduced by NaI / acetic acid, along with concurrent cyclization and cleavage of the seven-membered heterocycle from the PEG support.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Benzodiazepinas
/
Técnicas de Química Combinatória
/
Nitrogênio
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article