Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET.
Int J Radiat Oncol Biol Phys
; 67(1): 91-6, 2007 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-17189066
ABSTRACT
PURPOSE:
A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer. METHODS AND MATERIALS Eleven patients who underwent an [(18)F]-fluoro-deoxy-D-glucose (FDG)-PET in conjunction with their first, middle, or last brachytherapy treatment were included in this prospective study. A standard plan that delivers 6.5 Gy to point A under ideal conditions was compared with an optimized plan designed to conform the 6.5-Gy isodose surface to the PET defined volume.RESULTS:
A total of 31 intracavitary brachytherapy treatments in conjunction with an FDG-PET were performed. The percent coverage of the target isodose surface for the first implant with and without optimization was 73% and 68% (p = 0.21). The percent coverage of the target isodose surface for the mid/final implant was 83% and 70% (p = 0.02), respectively. The dose to point A was higher with the optimized plans for both the first implant (p = 0.02) and the mid/last implants (p = 0.008). The dose to 2 cm(3) and 5 cm(3) of both the bladder and rectum were not significantly different.CONCLUSIONS:
FDG-PET based treatment planning allowed for improved dose coverage of the tumor without significantly increasing the dose to the bladder and rectum.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Imagem Assistida por Computador
/
Planejamento da Radioterapia Assistida por Computador
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Braquiterapia
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Neoplasias do Colo do Útero
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Compostos Radiofarmacêuticos
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Fluordesoxiglucose F18
Tipo de estudo:
Evaluation_studies
/
Observational_studies
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article