Removal of acid-labile protecting groups on carbohydrates using water-tolerant and recoverable vanadyl triflate catalyst.
J Org Chem
; 72(1): 299-302, 2007 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-17194117
ABSTRACT
Acetal, trityl, and TBDMS protecting groups on saccharides were subjected to alcoholysis using a catalytic amount of vanadyl triflate in an MeOH-CH2Cl2 solvent system. The configuration at the anomeric positions of saccharides was retained, and no glycosidic bond cleavage and oxidation of sulfides were observed. The presented method was easily implemented, compatible with diverse functional groups, and regioselective in some cases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos
/
Carboidratos
/
Vanadatos
/
Água
/
Mesilatos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article