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A potent and orally active HIV-1 integrase inhibitor.
Egbertson, Melissa S; Moritz, H Marie; Melamed, Jeffrey Y; Han, Wei; Perlow, Debra S; Kuo, Michelle S; Embrey, Mark; Vacca, Joseph P; Zrada, Matthew M; Cortes, Amanda R; Wallace, Audrey; Leonard, Yvonne; Hazuda, Daria J; Miller, Michael D; Felock, Peter J; Stillmock, Kara A; Witmer, Marc V; Schleif, William; Gabryelski, Lori J; Moyer, Gregory; Ellis, Joan D; Jin, Lixia; Xu, Wei; Braun, Matthew P; Kassahun, Kellem; Tsou, Nancy N; Young, Steven D.
Afiliação
  • Egbertson MS; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. melissa_egbertson@merck.com
Bioorg Med Chem Lett ; 17(5): 1392-8, 2007 Mar 01.
Article em En | MEDLINE | ID: mdl-17194584
ABSTRACT
A 1,6-naphthyridine inhibitor of HIV-1 integrase has been discovered with excellent inhibitory activity in cells, good pharmacokinetics, and an excellent ability to inhibit virus with mutant enzyme.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Integrase de HIV / Naftiridinas Limite: Animals / Humans Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Integrase de HIV / Naftiridinas Limite: Animals / Humans Idioma: En Ano de publicação: 2007 Tipo de documento: Article