Solution-phase parallel synthesis of 3,5,6-substituted indolin-2-ones.
J Comb Chem
; 9(1): 86-95, 2007.
Article
em En
| MEDLINE
| ID: mdl-17206836
ABSTRACT
A practical and efficient new parallel method has been developed for the synthesis of 3-substituted indolin-2-ones with a large variety of substituents at the 5- and 6-positions using 1,5-difluoro-2,4-dinitrobenzene. This 3,5,6-substituted indolin-2-one skeleton possesses three points of diversification and, thus, affords new opportunities for identification and optimization of leads in drug discovery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dinitrofluorbenzeno
/
Indóis
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article