TLR ligands differentially affect uptake and presentation of cellular antigens.
Blood
; 109(9): 3890-4, 2007 May 01.
Article
em En
| MEDLINE
| ID: mdl-17218388
ABSTRACT
Dendritic cells (DCs) have the unique ability to efficiently present T-cell epitopes from exogenous antigens on MHC class I molecules, a process called cross-presentation. In our study we demonstrate that stimulation of monocyte-derived DCs with Toll-like receptor (TLR) ligands differentially affects the uptake and cross-presentation of cellular antigens. Activation of DCs with TLR3 or TLR4 but not with TLR2 or TLR7/8 ligands inhibited phagocytosis of apoptotic tumor cells and resulted in a reduced cross-presentation of pp65-derived T-cell epitopes on MHC class I molecules upon engulfment of cytomegalovirus (CMV)-infected fibroblasts. These results have an important impact on the understanding of the interactions between the immune system and pathogens and the development of vaccination strategies to treat malignant diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Antígenos de Histocompatibilidade Classe I
/
Apresentação de Antígeno
/
Infecções por Citomegalovirus
/
Epitopos de Linfócito T
/
Receptores Toll-Like
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article