Lack of effect of perindopril on plasma and adrenal corticosteroids in the guinea pig during the estrous cycle and under contraceptive treatment.
Arch Int Physiol Biochim Biophys
; 99(4): 287-90, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1723316
ABSTRACT
We studied changes in cortisol, aldosterone, progesterone, estrogens and cholesterol in cyclic female guinea-pigs and in animals under contraceptive, treated or not with an inhibitor of angiotensin converting enzyme (ACE) perindopril. Perindopril decreased ACE by 80% without affecting steroid profiles. Peak value for plasma progesterone occurred at meta-estrus and diestrus. It disappeared under contraceptive treatment. The very low levels of estrogens in the female guinea pig remained unchanged in all cases. Plasma cortisol concentrations were higher at pro-estrus and estrus whereas plasma aldosterone concentrations remained constant during the estrous cycle and under contraceptive treatment. Furthermore, aldosterone did not change under perindopril treatment despite the decrease of the activity of ACE. The contraceptive treatment decreased plasma cholesterol levels. Under perindopril treatment, this drop was amplified. No change was detected in adrenal steroid concentrations, except for progesterone which decreased under contraceptive treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estro
/
Inibidores da Enzima Conversora de Angiotensina
/
Corticosteroides
/
Glândulas Suprarrenais
/
Anticoncepcionais Femininos
/
Indóis
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article