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IL-6 immunoreactivity changes during aging in the polychaete Ophryotrocha labronica (Polychaeta: Dorvilleidae).
Franchini, A; Ottaviani, E.
Afiliação
  • Franchini A; Department of Animal Biology, University of Modena and Reggio Emilia, via Campi 213/D, Modena, Italy. franchini.antonella@unimore.it
Tissue Cell ; 39(1): 27-34, 2007 Feb.
Article em En | MEDLINE | ID: mdl-17258255
IL-6 is a pleiotropic pro-inflammatory cytokine thought to play a role in age physiology, even if its possible modulation by aging mechanisms has not been fully defined. In this paper, the morpho-functional modifications and IL-6 immunoreactivity during aging in a simple invertebrate model, Ophryotrocha labronica, are reported. The comparison between newly-hatched, juveniles, young adult and 3-month-old females showed significant differences in the nervous and genital systems. There is evidence of nerve cell loss and a decline in oocyte growth and maturation at the gonad level. Immunohistochemistry reveals a different distribution of IL-6-like molecules, and a decreased number of reactive nerve cells in the central nervous system of aged O. labronica associated to the induced morphological modifications.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliquetos / Envelhecimento / Interleucina-6 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliquetos / Envelhecimento / Interleucina-6 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2007 Tipo de documento: Article