Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.
Bioorg Med Chem Lett
; 17(7): 1930-3, 2007 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-17270443
ABSTRACT
The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Delta21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Pirrolidinas
/
Replicon
/
RNA Polimerase Dependente de RNA
/
Química Farmacêutica
/
Proteínas não Estruturais Virais
/
Hepacivirus
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article